• Valentina Donato, Alberto Noto, Antonio Lacquaniti, Davide Bolignano, Antonio Versaci, Antonio David, Francesco Spinelli, and Michele Buemi.
• Department of Internal Medicine at the University of Messina in Messina, Italy.
• Am. J. Crit. Care. 2011 Sep 1;20(5):405-9.

AbstractNeutrophil gelatinase-associated lipocalin is one of the most promising biomarkers for the diagnosis of acute kidney injury. An increase in the level of neutrophil gelatinase-associated lipocalin is a good predictor of acute kidney injury and is associated with an increase in the serum level of creatinine. Two victims of a mudslide in Messina, Italy, initially had crush syndrome followed by development of acute kidney injury. The development of acute kidney injury is the second most common cause of death after large earthquakes and other natural disasters, but at the same time, crush-related acute kidney injury is one of the few life-threatening complications of crush injuries that can be reversed if diagnosed early and treated. In this case, measuring the level of neutrophil gelatinase-associated lipocalin enabled early diagnosis of acute kidney injury and anticipation of the changes in levels of conventional markers such as creatinine.

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