• T Uchida, H Ogino, M Ando, Y Okita, T Yagihara, and S Kitamura.
• Department of Cardiovascular Surgery, National Cardiovascular Center, Suita, Japan.
• Kyobu Geka. 2002 Jul 1;55(8 Suppl):693-6.

AbstractIn patients with Marfan syndrome, pregnancy is associated with a potential higher risk of aortic dissection. To determine the incidence and characteristics of aortic dissection in pregnancy, clinical courses of 8 patients with Marfan syndrome were reviewed. Aortic dissection occurred in 3 patients, one of whom had developed rapid dilatation of the ascending aorta during pregnancy. The patient underwent Bentall operation subsequent to cesarean section and simple hysterectomy. All patients tolerated pregnancy well, with favorable maternal and fetal outcomes. Follow-up echocardiography showed no apparent worsening of cardiovascular status attributable to pregnancy such as aortic dilatation and aortic regurgitation except for one patient. Dilatation of the ascending aorta during pregnancy is considered to be an important predictor for aortic dissection. Close observation should be mandatory in such patients. In patients with serious cardiovascular involvement such as acute aortic dissection, cesarean section is preferable for delivery. To prevent hemorrhagic complications under systemic heparinization, simultaneous hysterectomy should be considered as one option.

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