• Headache · Mar 2007

    Case Reports

    Prophylaxis of hemicrania continua: two new cases effectively treated with topiramate.

    • Filippo Brighina, Antonio Palermo, Giuseppe Cosentino, and Brigida Fierro.
    • Department of Neurology, University of Palermo, Palermo, Italy.
    • Headache. 2007 Mar 1;47(3):441-3.

    AbstractHemicrania continua (HC) is an uncommon and under-recognized primary headache disorder characterized by a strictly unilateral continuous headache of moderate intensity with possible exacerbations and associated with ipsilateral autonomic features. HC has generally a prompt and enduring response to indomethacin although 25% to 50% of treated patients develop gastrointestinal side effects. These cases pose a difficult management challenge as no other drug is consistently effective in HC. Recently 2 HC patients responsive to topiramate treatment have been reported. Here we describe 2 more patients effectively treated with topiramate. Neither reported any side effects and one had persisting response for 6 months after drug withdrawal.

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