• Eur J Ophthalmol · Jul 2010

    Case Reports

    Fundus autofluorescence and spectral domain optical coherence tomography in early detection of Plaquenil maculopathy.

    • Amy T Kelmenson, Vikram S Brar, Ravi K Murthy, and Kakarla V Chalam.
    • Department of Ophthalmology, University of Florida College of Medicine, Jacksonville, FL 32209, USA.
    • Eur J Ophthalmol. 2010 Jul 1;20(4):785-8.

    PurposeTo report fundus autofluorescence (FAF) and spectral-domain optical coherence tomography (SD-OCT) findings in a patient with early hydroxychloroquine maculopathy.MethodsA 50-year-old man presented with complaints of ring-like shadows in front of his eyes. He had been on hydroxychloroquine (Plaquenil) 400 mg orally twice daily for 10 years (5.14 mg/kg/day). Fundus examination revealed granular hypopigmentation in an arcuate pattern in the inferior parafoveal area bilaterally. The patient underwent further evaluation with SD-OCT and FAF imaging. Functional changes were assessed by microperimetry.ResultsHypopigmented lesions on the fundus were autofluorescent and SD-OCT corresponding to this area revealed loss of inner segment-outer segment, suggesting loss of photoreceptor layer in the affected area with underling dysfunctional retinal pigment epithelium.ConclusionsFindings on SD-OCT and FAF imaging support the histopathologic findings described in cases of hydroxychloroquine maculopathy.

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