• J Pain Palliat Care Pharmacother · Jan 2008

    Conversion from parenteral to oral methadone.

    • Jesús González-Barboteo, Josep Porta-Sales, Daniel Sánchez, Albert Tuca, and Xavier Gómez-Batiste.
    • Palliative Care Service, Institut Català d'Oncologia, L'Hospitalet de Llobregat, Barcelona, Spain. jgonzalez@ico.scs.es
    • J Pain Palliat Care Pharmacother. 2008 Jan 1; 22 (3): 200-5.

    AbstractThe described ratio for methadone conversion from oral route (PO) to parenteral route (PAR) is 2:1 and from PAR to PO is 1:2. Frequently, good control of pain with methadone is PR to PO. We use methadone as a function of opioid rotation and not in the context of mortality outcome and we have noted that the traditional ratio produces toxicity problems. We present our experience with patients who we converted from PAR to PO methadone and we recommend a conversion ratio of 0.7 (PO:PAR = 1:0.7), which approximates the bioavailability of the drug administered orally.

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