• Pharmacology · Jan 2014

    Additive effect of combined application of magnesium and MK-801 on analgesic action of morphine.

    • Magdalena Bujalska-Zadrożny and Kamila Duda.
    • Department of Pharmacodynamics, Medical University of Warsaw, Warsaw, Poland.
    • Pharmacology. 2014 Jan 1;93(3-4):113-9.

    AbstractAs previously reported, magnesium ions (Mg(2+)) administered in relatively low doses markedly potentiated opioid analgesia in neuropathic pain, in which the effectiveness of opioids is limited. Considering that Mg(2+) behaves like an N-methyl-D-aspartate receptor antagonist, the effect of this ion on the analgesic action of morphine was compared with that of MK-801. Acute pain was evoked by mechanical or thermal stimuli, whereas neuropathic hyperalgesia was induced by streptozotocin (STZ) administration. Magnesium sulphate (40 mg/kg i.p.) or MK-801 (0.05 mg/kg s.c.) administered alone did not modify the nociceptive threshold to acute stimuli or the streptozotocin hyperalgesia but significantly augmented the analgesic action of morphine (5 mg/kg i.p.). Furthermore, if these drugs (i.e. magnesium sulphate and MK-801) were applied concomitantly, a clear additive effect on the analgesic action of morphine occurred in both models of pain. Possible explanations of these observations are discussed.© 2014 S. Karger AG, Basel.

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