• Bioorg. Med. Chem. Lett. · Sep 2002

    Quaternary salts of E2020 analogues as acetylcholinesterase inhibitors for the reversal of neuromuscular block.

    • John K Clark, Phill Cowley, Alan W Muir, Ronald Palin, Eleanor Pow, Alan B Prosser, Robert Taylor, and Ming-Qiang Zhang.
    • Department of Medicinal Chemistry, Organon Laboratories Ltd., Newhouse, Lanarkshire ML1 5SH, UK. jk.clark@organon@co.uk
    • Bioorg. Med. Chem. Lett. 2002 Sep 16;12(18):2565-8.

    AbstractA series benzylpiperidinium and benzylpyridinium quaternary salts have been synthesised and tested for inhibition of acetylcholinesterase and reversal of neuromuscular block induced by vecuronium. Several potent reversal agents have been identified and their haemodynamic effects measured.

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