• Am. J. Cardiol. · Jan 2007

    Review

    An orwellian discourse on the meaning and measurement of noninferiority.

    • George A Diamond and Sanjay Kaul.
    • Division of Cardiology, Cedars-Sinai Medical Center, Los Angeles, California, USA. gadiamond@pol.net
    • Am. J. Cardiol. 2007 Jan 15;99(2):284-7.

    AbstractThe customary interpretation of active-controlled noninferiority trials is founded on a number of unverifiable assumptions. These assumptions can be circumvented, and the semantic and statistic interpretation of the trials placed on a more rational foundation, if treatment comparisons are analyzed from a Bayesian perspective. In conclusion, the resultant probabilistic measures thereby render the meaning of noninferiority more transparent and clinically relevant.

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