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Semin Cardiothorac Vasc Anesth · Mar 2009
ReviewPhysiology and pharmacology of myocardial preconditioning and postconditioning.
- Julie Huffmyer and Jacob Raphael.
- Department of Anesthesiology, University of Virginia Health Sciences System, Charlottesville, Virginia 22908, USA.
- Semin Cardiothorac Vasc Anesth. 2009 Mar 1;13(1):5-18.
AbstractPerioperative myocardial ischemia and infarction are not only major sources of morbidity and mortality in patients undergoing surgery but also important causes of prolonged hospital stay and resource utilization. Ischemic and pharmacological preconditioning and postconditioning have been known for more than 2 decades to provide protection against myocardial ischemia and reperfusion and limit myocardial infarct size in many experimental animal models, as well as in clinical studies. This article reviews the physiology and pharmacology of ischemic and drug-induced preconditioning and postconditioning of the myocardium with special emphasis on the mechanisms by which volatile anesthetics provide myocardial protection. Insights gained from animal and clinical studies are reviewed and recommendations given for the use of perioperative anesthetics and medications.
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