• Clin. Lab. Med. · Sep 2014

    Review Comparative Study

    Prothrombin complex concentrates as reversal agents for new oral anticoagulants: lessons from preclinical studies with Beriplex.

    • Gerhard Dickneite.
    • CSL Behring, Preclinical R&D, PO Box 1230, Marburg 35002, Germany. Electronic address: Gerhard.Dickneite@cslbehring.com.
    • Clin. Lab. Med. 2014 Sep 1;34(3):623-35.

    AbstractAlthough new oral anticoagulants (NOACs) represent an advance in anticoagulant therapy over vitamin K antagonists (VKAs), they nevertheless have a low, but significant risk for bleeding complications. Reversal agents for VKAs, such as prothrombin complex concentrates (PCCs), are currently being evaluated in preclinical studies for NOAC reversal. This article reviews the preclinical data for the most extensively studied PCC for NOAC reversal, Beriplex, a 4-factor PCC. The results from the Beriplex studies are also compared with those obtained with other reversal agents, including different nonactivated PCCs, activated PCCs, and recombinant activated factor VII.Copyright © 2014 Elsevier Inc. All rights reserved.

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