• Curr Pain Headache Rep · Jan 2014

    Review

    Intrathecal therapy for chronic pain: current trends and future needs.

    • Salim M Hayek and Michael C Hanes.
    • Department of Anesthesiology, Case Western Reserve University, Cleveland, OH, 44106, USA, salim.hayek@uhhospitals.org.
    • Curr Pain Headache Rep. 2014 Jan 1;18(1):388.

    AbstractThe management of chronic pain continues to pose many challenges to healthcare providers. Intrathecal drug delivery systems (IDDS) provide an effective therapy for patients suffering from chronic pain intractable to medical management. However, the clinical growth of intrathecal therapy continues to face many challenges, and is likely underutilized secondary to its high-complexity and limited reimbursement. The clinical utility of IDDS remains limited by lack of prospective randomized, placebo-controlled studies. In addition, there remains a need to enhance physician knowledge on the pharmacodynamics and pharmacokinetics of intrathecal drug delivery and promote further research into this field and drug delivery modalities. The purpose of this article is to provide a comprehensive review of the determinants of successful intrathecal drug delivery with an emphasis on its use in noncancer pain.

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