• Forensic Sci. Int. · Feb 2007

    The detection of sedatives in hair and nail samples using tandem LC-MS-MS.

    • Rachel C Irving and Stuart J Dickson.
    • Department of Chemistry, The University of Waikato, Knighton Road, Hamilton, New Zealand.
    • Forensic Sci. Int. 2007 Feb 14;166(1):58-67.

    AbstractDrug screening methods were developed to detect alprazolam, clobazam, clonazepam, diazepam, midazolam, oxazepam, temazepam, triazolam, zopiclone, and selected metabolites in human hair and nail samples employing liquid-liquid extraction and tandem liquid chromatography-mass spectrometry (LC-MS-MS). Hair and nail samples were obtained from patients who had recently discontinued or were currently prescribed one or more of the targeted drugs. Prazepam was used as the internal standard for all compounds. Some components in the hair matrix gave the same transitions as some of the analytes but did not compromise the analyses because their retention times differed from those for the target compounds. The analytical run time was 8-10min. Results of the hair analysis of a DFSA victim are also presented.

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