• Clin. Lab. Med. · Sep 2014

    Review Comparative Study

    Four-factor prothrombin complex concentrate versus plasma for urgent vitamin K antagonist reversal: new evidence.

    • Ravi Sarode.
    • Division of Transfusion Medicine and Hemostasis, Department of Pathology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9234, USA. Electronic address: ravi.sarode@utsouthwestern.edu.
    • Clin. Lab. Med. 2014 Sep 1;34(3):613-21.

    AbstractVitamin K antagonist (VKA) therapy is a mainstay of treatment for patients at risk of thromboembolic events. Despite widespread use, a major limitation of VKA therapy is the substantial risk of serious bleeding complications, which often require rapid reversal of anticoagulation. A recent randomized multicenter comparison between a 4-factor prothrombin complex concentrate (4F-PCC) and plasma in patients with acute major bleeding has provided important new evidence of the benefit of 4F-PCC over plasma for urgent VKA reversal.Copyright © 2014 Elsevier Inc. All rights reserved.

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