• Kathie L Hermayer, Patrick Cawley, Pamela Arnold, Angela Sutton, John Crudup, Lisa Kozlowski, Timothy V Hushion, Maureen L Sheakley, Juanita A Epps, Rebecca P Weil, and Rickey E Carter.
• Department of Medicine/Endocrinology, Medical University of South Carolina, Charleston, South Carolina 29425, USA. hermayer@musc.edu
• J Hosp Med. 2009 Jul 1;4(6):331-9.

BackgroundGreat emphasis is placed on optimizing treatment of hospitalized patients with diabetes and hyperglycemia.ObjectiveThis study was conducted to determine if the application of hospital-wide insulin order sets improved inpatient safety by reducing the number of actual hypoglycemic and hyperglycemic events and increasing at-target blood glucose.DesignA retrospective chart review was conducted of hypoglycemic and hyperglycemic events and at-target blood glucose occurring before and after institution of the insulin order sets and blood glucose protocols.SettingThe Medical University of South Carolina (MUSC) Medical Center is a 709-bed hospital and tertiary referral center for partnering hospitals in the southeastern United States.PatientsAll patients were evaluated who had a documented history of diabetes or who had at least 1 finger-stick blood glucose above 180 mg/dL who were admitted for care to the MUSC adult main hospital (minimum of 18 years-of-age; maximum 100 years-of-age) during June 2004, June 2005, June 2006, and June 2007.InterventionThe intervention involved institution of hospital-wide hypoglycemia, hyperglycemia, subcutaneous insulin, and intravenous insulin treatment protocols.MeasurementsRetrospective data on hypoglycemia, hyperglycemia, and at-target blood glucose incidence and frequency were collected via a computerized repository for all inpatients.ResultsThe percent time in range improved by 10% with no increase in the amount of severe hypoglycemic episodes for the blood glucose results.ConclusionsImplementing standardized insulin order sets including hypoglycemia and hyperglycemia treatment protocols at MUSC produced expected benefits for patient safety for this patient population.

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