• Giovanni Docimo, Salvatore Tolone, Giovanni Conzo, Paolo Limongelli, Gianmattia Del Genio, Domenico Parmeggiani, Maurizio De Palma, Gennaro Lupone, Nicola Avenia, Roberta Lucchini, Massimo Monacelli, Gaspare Gulotta, Gregorio Scerrino, Daniela Pasquali, Giuseppe Bellastella, Katherine Esposito, Annamaria De Bellis, Angela Pezzolla, Roberto Ruggiero, and Ludovico Docimo.
• Second University of Naples, Naples, Italy giovanni.docimo@unina2.it.
• Surg Innov. 2016 Feb 1; 23 (1): 23-9.

BackgroundHemostasis during thyroidectomy is essential; however, the safest, most efficient, and most cost-effective way to achieve this is unclear. This randomized, multicenter, single-blind, prospective study evaluated the efficacy and safety of using different hemostatic approaches in patients undergoing total thyroidectomy.MethodsPatients aged ≥18 to 70 years were randomized to Floseal + a harmonic scalpel (HS), Floseal alone, HS alone, or standard total thyroidectomy. Primary endpoint was 24-hour drain output. Secondary endpoints included surgery duration and complications.ResultsTwo hundred and six patients were randomized to Floseal + HS (n = 52), Floseal alone (n = 54), HS alone (n = 50), and standard total thyroidectomy (n = 50). The 24-hour drain output was lower in the Floseal + HS group compared with standard thyroidectomy. Floseal + HS also had a shorter surgery time (P < .0001) versus the other 3 treatments.ConclusionFloseal + HS can be effective at reducing postsurgical drain output and provides a complementary hemostatic approach in patients undergoing total thyroidectomy.© The Author(s) 2015.

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