Possible link of pioglitazone with bladder cancer in Japanese

Diabetes Res. Clin. Pract. · Feb 2013

Possible link of pioglitazone with bladder cancer in Japanese patients with type 2 diabetes.

We retrospectively examined the frequency of bladder cancer in Japanese patients with type 2 diabetes in relation to use of pioglitazone. Among a total of 663 patients identified to be taking pioglitazone, 9 had bladder cancer (1.36%). Overall the hazard ratio of 1.75 [95% CI: 0.89-3.45] for pioglitazone for bladder cancer was not significant. However the prevalence of bladder cancer was 2.10% in patients taking pioglitazone for less than 24 months which was significant increased (HR 2.73 [95% CI: 1.11-6.72]).

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- Kanta Fujimoto, Yoshiyuki Hamamoto, Sachiko Honjo, Yukiko Kawasaki, Kanako Mori, Hisato Tatsuoka, Atsuko Matsuoka, Yoshiharu Wada, Hiroki Ikeda, Jun Fujikawa, and Hiroyuki Koshiyama.
- Center for Diabetes and Endocrinology, Tazuke Kofukai Foundation Medical Research Institute Kitano Hospital, Osaka, Japan.
- Diabetes Res. Clin. Pract. 2013 Feb 1;99(2):e21-3.
AbstractWe retrospectively examined the frequency of bladder cancer in Japanese patients with type 2 diabetes in relation to use of pioglitazone. Among a total of 663 patients identified to be taking pioglitazone, 9 had bladder cancer (1.36%). Overall the hazard ratio of 1.75 [95% CI: 0.89-3.45] for pioglitazone for bladder cancer was not significant. However the prevalence of bladder cancer was 2.10% in patients taking pioglitazone for less than 24 months which was significant increased (HR 2.73 [95% CI: 1.11-6.72]).Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

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Possible link of pioglitazone with bladder cancer in Japanese patients with type 2 diabetes.

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