• The Journal of infection · Sep 2013

    Community-acquired pneumonia during the first post-pandemic influenza season: a prospective, multicentre cohort study.

    • Diego Viasus, Carmen Marinescu, Aroa Villoslada, Elisa Cordero, Juan Gálvez-Acebal, María C Fariñas, Irene Gracia-Ahufinger, Anabel Fernández-Navarro, Jordi Niubó, Lucia Ortega, Elena Muñez-Rubio, María P Romero-Gómez, Jordi Carratalà, and Influenza A (H1N1) Study Group of the Spanish Network for Research in Infectious Diseases (REIPI).
    • Hospital Universitari de Bellvitge - IDIBELL, University of Barcelona, Feixa Llarga s/n, 08907 Barcelona, Spain. dfviasusp@gmail.com
    • J. Infect. 2013 Sep 1;67(3):185-93.

    ObjectivesTo determine the aetiology, clinical features and prognosis of CAP during the first post-pandemic influenza season. We also assessed the factors associated with severe disease and tested the ability of a scoring system for identifying influenza A (H1N1)pdm09-related pneumonia.MethodsProspective cohort study carried out at 10 tertiary hospitals of Spain. All adults hospitalised with CAP from December 01, 2010 to March 31, 2011 were analysed.ResultsA total of 747 adults with CAP required hospitalisation. The aetiology was determined in 315 (42.2%) patients, in whom 154 (21.9%) were due to bacteria, 125 (16.7%) were due to viruses and 36 (4.8%) were mixed (due to viruses and bacteria). The most frequently isolated bacteria were Streptococccus pneumoniae. Among patients with viral pneumonia, the most common organism identified were influenza A (H1N1)pdm09. Independent factors associated with severe disease were impaired consciousness, septic shock, tachypnea, hyponatremia, hypoxemia, influenza B, and influenza A (H1N1)pdm09. The scoring system evaluated did not differentiate reliably between patients with influenza A (H1N1)pdm09-related pneumonia and those with other aetiologies.ConclusionsThe frequency of bacterial and viral pneumonia during the first post-pandemic influenza season was similar. The main identified virus was influenza A (H1N1)pdm09, which was associated with severe disease. Although certain presenting clinical features may allow recognition of influenza A (H1N1)pdm09-related pneumonia, it is difficult to express them in a reliable scoring system.Copyright © 2013 The British Infection Association. Published by Elsevier Ltd. All rights reserved.

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