• Neuroscience letters · Apr 2014

    Alteration of nerve growth factor in dorsal root ganglia at early time of acute myocardial infarction and the role of spinal nerve afferents.

    • Zheng Guo and Wei Yue.
    • Department of Anesthesiology, Shanxi Medical University and Second Hospital of Shanxi Medical University, 56 Xinjian Nan Road, Taiyuan 030001, Shanxi, China; Key Laboratory of Cellular Physiology, Shanxi Medical University, National Education Commission, Taiyuan, China. Electronic address: guozheng713@163.com.
    • Neurosci. Lett. 2014 Apr 3;564:1-5.

    AbstractNerve growth factor (NGF) plays important roles in transmission of nociception, neural innervation and survival in sympathetic and sensory neurons. Evidence indicates that NGF may sensitize the sensory and sympathetic reaction upon noxious stimulation. Understanding of the alterations of NGF in the sensory neurons during acute myocardial infarction and the underlying mechanism may promote clinical prognosis of the pathology. The aim of the study was to investigate the changes of NGF in the sensory neurons innervating the heart at early time after myocardial infarction and potential role of afferent nerve signals in modulation of NGF. The myocardial infarction was induced by ligation of the left anterior descending branch of coronary artery in anesthetized rats. The expressions of NGF and its coding mRNA in the sensory neurons in the dorsal root ganglia of upper thoracic segments (1-5), with and without prior blockade of the spinal nerves, were examined using immunohistochemical assay, enzyme-linked immunosorbent assay and real-time quantitative reverse transcription polymerase chain reaction assay. It was found that the immunoreactive material for NGF was significantly increased in the ganglia (P<0.05) at 60min of myocardial infarction, without change in NGF mRNA before and after the time. Blockade of the spinal nerves obviously inhibited the expression of NGF (P<0.05) and the coding mRNA (P<0.01). The results may indicate that the spinal nerve afferents are important in sustaining and up-regulating the expression of NGF in the sensory neurons innervating the heart in acute myocardial infarction.Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…

What will the 'Medical Journal of You' look like?

Start your free 21 day trial now.

We guarantee your privacy. Your email address will not be shared.