• Surg Neurol · Sep 2009

    Review Case Reports

    Intracranial aneurysms in sickle cell patients: report of 2 cases and review of the literature.

    • Rafael Augusto Castro Santiago Brandão, Gervásio Teles C de Carvalho, Baltazar Leão Reis, Enderson Bahia, and Atos Alves de Souza.
    • Department of Neurosurgery, Santa Casa Hospital, Faculty of Medical Science of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. rafabrand@gmail.com
    • Surg Neurol. 2009 Sep 1;72(3):296-9; discussion 299.

    BackgroundThe sickle cell disease has different neurologic complications, including cerebral aneurysms. This disease may lead to endothelial damage, which favors the development of cerebral aneurysms. Only a few cases demonstrated by cerebral angiography or surgery have been reported in the English literature referring to cerebral aneurysms in sickle cell patients.Case DescriptionWe report 2 patients with sickle cell disease whose cerebral aneurysms were successfully treated by open surgery.ConclusionSickle cell patients have a high occurrence of multiple aneurysms, and a high prevalence of posterior circulation aneurysms. This must be interpreted with caution, and further studies are needed to confirm this association.

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