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- Rubin M Tuder, Elvira Stacher, Jeffrey Robinson, Rahul Kumar, and Brian B Graham.
- Program in Translational Lung Research, Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado School of Medicine, 12700 East 19th Avenue, Research Complex 2, Room 9001, Aurora, CO 80045, USA. Electronic address: rubin.tuder@ucdenver.edu.
- Clin. Chest Med. 2013 Dec 1;34(4):639-50.
AbstractThe pathology of pulmonary hypertension includes numerous abnormalities of the intima, media, and adventitia of the pulmonary vascular tree. A recently completed systematic analysis revealed high variability of morphologic measurements within a given pulmonary arterial hypertension (PAH) lung and among all PAH lungs, as well as distinct pathologic subphenotypes, and included a subset of lungs lacking intimal and medial remodeling. There was correlation between perivascular inflammation, remodeling, and hemodynamics. This article summarizes the pathologic features of the normal and abnormal pulmonary circulation, and correlations with animal models.Copyright © 2013 Elsevier Inc. All rights reserved.
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