• Shu Zou, Jian Wang, Wenqi Pan, Yong Zheng, and Bo Huang.
• Department of Orthopedics, Affiliated Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, P R China.
• Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2013 Aug 1;27(8):960-4.

ObjectiveTo compare the difference of traumatic related index in serum and its significance between minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) and open TLIF.MethodsSixty patients were enrolled by the entry criteria between May and November 2012, and were divided into MIS-TLIF group (n = 30) and open TLIF group (n = 30). There was no significant difference in gender, age, type of lesions, disease segment, and disease duration between 2 groups (P > 0.05). The operation time, intraoperative blood loss, and postoperative hospitalization time were recorded, and the pain severity of incision was evaluated by visual analog scale (VAS). The serum levels of C-reactive protein (CRP) and creatine kinase (CK) were measured at preoperation and at 24 hours postoperatively. The levels of interleukin 6 (IL-6), IL-10, and tumor necrosis factor alpha (TNF-alpha) in serum were measured at preoperation and at 2, 4, 8, and 24 hours after operation.ResultsThe operation time, intraoperative blood loss, and postoperative hospitalization time of MIS-TLIF group were significantly smaller than those of open TLIF group (P < 0.05), and the VAS score for incision pain in MIS-TLIF group was significantly lower than that of open TLIF group at 1, 2, and 3 days after operation (P < 0.05). The levels of CRP, CK, IL-6, and IL-10 in MIS-TLIF group were significantly lower than those in open TLIF group at 24 hours after operation (P < 0.05), but there was no significant difference between 2 groups before operation (P > 0.05). No significant difference was found in TNF-alpha level between 2 groups at pre- and post-operation (P > 0.05).ConclusionCompared with the open-TLIF, MIS-TLIF may significantly reduce tissue injury and systemic inflammatory reactions during the early postoperative period.

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