• Anukul Garg and Mark P J Vanderpump.
• Department of Endocrinology, Royal Free London NHS Foundation Trust, Pond Street, London NW3 2QG, UK.
• Br. Med. Bull. 2013 Jan 1;107:101-16.

IntroductionSubclinical thyroid disease is a common finding on testing of thyroid function and its management remains controversial.Source Of DataEpidemiological data from large population studies from USA and Europe.Areas Of AgreementThere is an increased risk of progression to overt hypothyroidism or hyperthyroidism. The treatment of mild thyroid failure is of importance in optimizing pregnancy outcome.Areas Of ControversyDiagnostic criteria differ and there is variation between management guidelines. The difference was found in long-term clinical outcomes between endogenous and exogenous subclinical hyperthyroidism.Growing PointsMeta-analyses have provided epidemiological data in cardiovascular mortality and morbidity in subclinical thyroid disease. Increased use of echocardiography and bone markers in identifying those who benefit from intervention.Areas Timely For Developing ResearchA randomized controlled trial to identify those subjects identified from screening programmes that benefit from intervention in terms of morbidity and mortality.

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