• Kazuhiro Kurokawa, Koji Mizuno, Masahiro Shibasaki, and Seitaro Ohkuma.
• Department of Pharmacology, Kawasaki Medical School, Matsushima, Kurashiki, Japan.
• J. Neurochem. 2010 Dec 1;115(5):1206-14.

AbstractLittle is known about ryanodine receptors (RyRs) related to the methamphetamine (METH)-induced place preference. The present study was designed to ascertain whether RyRs could play a role in the development of METH-induced place preference in the mouse. The METH-induced place preference was dose-dependently suppressed by dantrolene, a RyRs receptor antagonist. The levels of RyRs 1 and 2 in the frontal cortex and RyRs 1 in the limbic forebrain were significantly increased in METH-conditioned mice. This up-regulation of RyRs were not inhibited by nifedipine. Both the dopamine D(1) receptor antagonist SCH23390 and the dopamine D(2) receptor antagonist sulpiride inhibited the development of METH-induced place conditioning. In contrast, the increases of RyRs 1 and 2 in the frontal cortex and of RyRs 1 in the limbic forebrain were completely abolished by SCH23390, whereas sulpiride had no effect. These findings indicate that up-regulation of RyRs is regulated through the activation of dopamine D(1) receptors in the METH-conditioning.© 2010 The Authors. Journal of Neurochemistry © 2010 International Society for Neurochemistry.

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