• Am. J. Kidney Dis. · Feb 2015

    Case Reports

    Intratubular hemoglobin casts in hemolysis-associated acute kidney injury.

    • Mazdak A Khalighi, Kammi J Henriksen, Anthony Chang, and Shane M Meehan.
    • Department of Pathology, University of Chicago, Chicago, IL. Electronic address: maz.a.khalighi@gmail.com.
    • Am. J. Kidney Dis. 2015 Feb 1;65(2):337-41.

    AbstractKidney injury is a complication of intravascular hemolysis associated with many forms of hemolytic disease. Reports of kidney biopsy findings in patients with hemolysis-related kidney injury have focused primarily on the accumulation of hemosiderin pigment within proximal tubular epithelial cells (hemosiderosis), a feature of chronic hemolysis. The nephrotoxic effects of hemoglobin include direct cytotoxicity to tubular cells, but hemoglobin also can precipitate in distal nephron segments, forming obstructive casts. We present a case of hemolysis-associated tubular injury, characterized by acute onset of intravascular hemolysis followed by acute kidney injury with acute tubular injury and abundant intratubular casts containing hemoglobin.Copyright © 2015 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.

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