• Chun-Cheng Chiu, Yi-Nong Li, Leng-Jye Lin, Cheng-Ting Hsiao, Kuang-Yu Hsiao, and I-Chuan Chen.
• Department of Emergency Medicine, Chang Gung Memorial Hospital, No. 6 W. Sec., Jiapu Road, Puzih City, Chiayi County 613, Taiwan.
• J Clin Neurosci. 2012 Jun 1;19(6):810-3.

AbstractIt has been found that the hemostatic system is activated following a brain injury. To explore the role of D-dimer in spontaneous intracerebral hemorrhage (ICH), this prospective study aimed to evaluate the association between serum D-dimer concentration, clinical outcome and radiographic findings of ICH patients in the emergency department (ED). Patients with acute (<24 hours) spontaneous ICH were enrolled in this study. The D-dimer concentration was related to: baseline ICH volume (r=0.198, p=0.01); Glasgow Coma Scale (GCS) score 3-8 (p=0.01); GCS score 13-15 (p=0.002); midline shift >15 mm (p=0.016); and to subarachnoid extension of the blood (p<0.0001). Diabetes mellitus (odds ratio [OR]: 2.93; 95% confidence interval [CI]: 1.1-7.76, p=0.031), ICH volume (OR: 1.16; 95% CI: 1.07-1.27, p<0.0001) and D-dimer concentration (OR: 2.72; 95% CI: 1.08-6.9, p=0.002) were associated with 30-day mortality. This study shows that in patients with spontaneous ICH, a higher initial D-dimer concentration is associated with higher 30-day mortality.Copyright © 2011 Elsevier Ltd. All rights reserved.

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