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Antimicrob. Agents Chemother. · Dec 2003
Clinical TrialLinezolid penetration into bone and joint tissues infected with methicillin-resistant staphylococci.
- Friedrich Kutscha-Lissberg, Ute Hebler, Gert Muhr, and Manfred Köller.
- Department of Surgery-Trauma Center, BG Kliniken Bergmannsheil-Universitätsklinik, Ruhr University, Bochum, Germany. Friedrich.Kutscha-Lissberg@ruhr-uni-bochum.de
- Antimicrob. Agents Chemother. 2003 Dec 1;47(12):3964-6.
AbstractPenetration of linezolid into bone and joint tissues was studied by high-performance liquid chromatography in 13 patients suffering from implant-associated infections with methicillin-resistant staphylococci. Mean concentrations of linezolid in infected tissues were greater than 10 mg/liter in a sampling time range of 35 to 124 min after administration of the preoperative dose, except in bone specimens, where they reached 3.9 +/- 2.0 mg/liter.
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