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Ann Oto Rhinol Laryn · Jul 2013
Review Case ReportsMalignant transformation of respiratory papillomatosis in a solid-organ transplant patient: case report and literature review.
- Roya Azadarmaki and Miriam N Lango.
- Department of Surgery, Head and Neck Section, Fox Chase Cancer Center, Temple University Health System, Philadelphia, Pennsylvania, 19111, USA.
- Ann Oto Rhinol Laryn. 2013 Jul 1;122(7):457-60.
AbstractWe report the case of a 77-year-old non-smoker and non-drinker with a solid-organ transplant who had malignant transformation of respiratory papillomatosis 3 years after the initial diagnosis of this benign lesion. This is the first case reported in the literature of malignant transformation of respiratory papillomatosis in a solid-organ transplant patient. Virus-associated cutaneous cancers occur more frequently and aggressively in solid-organ transplant patients. There may be a higher rate of malignant transformation of respiratory papillomatosis in immunosuppressed patients, as this is a virus-associated disease. Closer observation, airway evaluation with laryngoscopy and tracheobronchoscopy, and interval biopsies of immunosuppressed patients with respiratory papillomatosis is recommended.
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