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- Mudiaga Sowho, Jason Amatoury, Jason P Kirkness, and Susheel P Patil.
- Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Johns Hopkins University, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA.
- Clin. Chest Med. 2014 Sep 1;35(3):469-81.
AbstractRespiration during sleep is determined by metabolic demand; respiratory drive is determined by a central respiratory generator. Changes in pharyngeal dilator muscle tone resulting in increased upper airway resistance and collapsibility contribute to hypoventilation. Relative hypotonia of respiratory muscles, body posture changes, and altered ventilatory control result in additional physiologic changes contributing to hypoventilation. This article reviews mechanisms of central control of respiration and normal upper and lower airway physiology. Understanding sleep-related changes in respiratory physiology will help in developing new therapies to prevent hypoventilation in susceptible populations.Copyright © 2014 Elsevier Inc. All rights reserved.
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