• Am J Prev Med · Mar 1997

    Historical Article

    Incidence of infectious disease and the licensure of immunobiologics in the United States.

    • D Campos-Outcalt and M Aickin.
    • Department of Family and Community Medicine, Maricopa Health System, Phoenix, Arizona, USA.
    • Am J Prev Med. 1997 Mar 1;13(2):98-103.

    IntroductionOur objective was to investigate the relationship of vaccine or toxoid licensure with the incidence of the target disease in the United States.MethodsWe used a historical correlational study design with outcome measures of the national incidence and elimination rate of polio, pertussis, diphtheria, and measles as well as the New York City incidence and elimination rate of mumps, rubella, and tetanus.ResultsThe licensure of pertussis, measles, polio, mumps, and rubella vaccine was followed by an increase in the elimination rate of disease. The elimination rates of diphtheria and tetanus apparently worsened following the licensure of the respective toxoids.ConclusionsHistorical data provide evidence of proof of efficacy of mass immunization for measles, polio, rubella, mumps, and pertussis, but not for diphtheria or tetanus.

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