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Randomized Controlled Trial
Lipoxin receptor agonist, may be a potential treatment for hemorrhagic shock-induced acute lung injury.
- Jie Gong, Hong-Bin Li, Si Guo, You Shang, and Shang-Long Yao.
- Department of Anaesthesiology and Critical Care, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
- Med. Hypotheses. 2012 Jul 1;79(1):92-4.
AbstractThe main pathogenesis of acute lung injury induced by hemorrhagic shock is increasingly recognized as an inflammatory process. BML-111, a lipoxin receptor agonist, has been demonstrated to promote acute inflammatory resolution by reduction of pro-inflammatory cytokines, attenuation of neutrophilic infiltration, and increasing macrophage phagocytosis of apoptotic neutrophils. Meanwhile, lipoxins and lipoxin analogues have been reported to play pro-resolving and anti-inflammatory effects in many disease models including cerebral ischemia, dorsal air pouch, peritonitis, and so on. Therefore, we hypothesize that BML-111 may be implicated in pathogenesis of hemorrhagic shock-induced acute lung injury.Copyright © 2012 Elsevier Ltd. All rights reserved.
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