• Surg. Clin. North Am. · Dec 2006

    Review

    Management of sepsis.

    • Gina Howell and Samuel A Tisherman.
    • University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
    • Surg. Clin. North Am. 2006 Dec 1;86(6):1523-39.

    AbstractSevere sepsis remains a common cause of death in surgical patients. Eradication of the septic source and supportive care has long been the mainstay of treatment. In recent years, however, early goal-directed therapy, tighter glucose control, administration of drotrecogin alfa (activated), and steroid replacement have produced improved morbidity and mortality. In the future, a better understanding of the pathophysiology of sepsis and clinical studies may further improve outcomes from severe sepsis.

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