• Ilias Karaiskos, Lambrini Galani, Fotini Baziaka, Emmanouela Katsouda, Ioannis Ioannidis, Alexandros Andreou, Harry Paskalis, and Helen Giamarellou.
• 6th Department of Internal Medicine, Hygeia General Hospital, 4 Erythrou Stavrou Str. & Kifissias Ave., Marousi 15123, Athens, Greece.
• Int. J. Antimicrob. Agents. 2013 May 1;41(5):480-3.

AbstractTreatment results of six post-neurosurgical ventriculitis and meningitis cases caused by extensively drug-resistant Acinetobacter baumannii after application of an intraventricular loading dose of 500000 IU (40 mg) of colistin followed by a dose of 125000-250000 IU (10-20 mg) every 24-48 h plus parenteral colistin are reported. Simultaneous bacteraemia with an identical Acinetobacter strain was observed in three patients. The mean duration of treatment was 17.2 days (range 15-21 days) and the median time of sterilisation of cerebrospinal fluid was 2.5 days (range 1-5 days). All patients were cured, however one patient presented with chemical meningitis and one with chemical ventriculitis, conditions that clinically and biochemically resemble bacterial meningitis.Copyright © 2013 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

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