• H Ishihara, T Iwakawa, T Hasegawa, M Muraoka, T Tsubo, and A Matsuki.
• Department of Anesthesiology, University of Hirosaki School of Medicine, Japan. ishihara@cc.hirosaki-u.ac.jp
• Intensive Care Med. 1999 Nov 1;25(11):1252-8.

ObjectiveTo determine whether plasma volume determined by the indocyanine green (ICG) dilution method (PV-ICG) is equally accurate independently of its disappearance rate from plasma in the critically ill.DesignRetrospective clinical investigation.SettingIntensive care unit of a university teaching hospital.Patients And Methods192 adult patients were initially enrolled. The PV-ICG and the initial distribution volume of glucose (IDVG) were calculated utilizing a one-compartment model by simultaneous administration of ICG 25 mg and glucose 5 g on the first day of measurement in each patient. Twenty-one patients were excluded from the study because of a higher PV-ICG/IDVG ratio (> 0.45) indicating apparent overestimation of the PV-ICG associated with the generalized protein capillary leakage. The remaining 171 patients were divided into four groups according to the magnitude of their disappearance rate of ICG from plasma (Ke-ICG).ResultsConvergence was assumed consistently in each ICG or glucose decay curve, even in the lower Ke-ICG less than 0.10/min. The relationship between the two volumes was not statistically different among groups.ConclusionsThe results suggest that the measurement of the PV-ICG can be equally accurate independently of its disappearance rate from plasma unless there is generalized protein capillary leakage.

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