• Der Internist · Aug 2013

    Case Reports

    [Dyspnoea, cough and B symptoms in a 40-year-old woman].

    • A Wolfensberger, R Benz, E W Russi, M Tinguely, C Keller, and B Gerber.
    • Klinik für Infektionskrankheiten und Spitalhygiene, UniversitätsSpital Zürich, Zürich, Schweiz.
    • Internist (Berl). 2013 Aug 1;54(8):1011-5.

    AbstractMulticentric Castleman's disease (MCD) is a rare polyclonal lymphoproliferative disorder that is typically accompanied by an overproduction of circulating cytokines (mainly interleukin-6). We here report the case of a 40-year-old HIV-negative woman with pulmonary manifestation of MCD. There is no standard treatment for MCD. In our patient, various treatment courses with immunomodulatory drugs were unsuccessful. Finally, treatment with the interleukin-6 receptor antibody tocilizumab has resulted in continual clinical improvement over the last 5 years.

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