• N Miyazawa, T Shinohara, and Z Yamagata.
• Department of PET Center, Kofu Neurosurgical Hospital, Kofu, Yamanashi, Japan. nobu_miya9311@yahoo.co.jp
• Eur. J. Neurol. 2011 Nov 1;18(11):1358-60.

Background And PurposeThis study investigated whether incompleteness of the anterior part of the circle of Willis affects the occurrence of lacunes in the basal ganglia.MethodsOne thousand and seventy-seven healthy individuals examined by magnetic resonance (MR) imaging and MR angiography were divided into eight subgroups according to our new classification.ResultsLogistic regression analysis demonstrated that healthy individuals with incompleteness of the anterior circle of Willis had significantly higher frequency of lacunes [odds ratio (OR): 2.121, 95% confidence interval (CI): 1.477-3.108; or OR: 2.46, 95% CI: 1.377-4.384 in cases without or with fetal type posterior communicating artery, respectively] and higher numbers of lacunes (P < 0.001 or P < 0.001 in cases without or with fetal type posterior communicating artery, respectively) compared to patients with complete circle of Willis.ConclusionsIncompleteness of the anterior part of the circle of Willis significantly affected the occurrence of lacunes.© 2011 The Author(s). European Journal of Neurology © 2011 EFNS.

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