• Cathelijne J M Alleman, Kirsten Y Westerhout, Marja Hensen, Colette Chambers, Malcolm Stoker, Stephen Long, and Floortje E van Nooten.
• Pharmerit B.V., Marten Meesweg 107, Rotterdam, The Netherlands. Electronic address: calleman@pharmerit.com.
• Diabetes Res. Clin. Pract. 2015 Aug 1; 109 (2): 215-25.

AimsPainful diabetic peripheral neuropathy (PDPN) is a common complication of diabetes mellitus. A systematic literature review was conducted to provide an overview of published literature in the last 10-years on the epidemiology, humanistic burden and economic burden of PDPN in Europe.MethodsA search was performed according to pre-defined strategy and review criteria in Embase, Pubmed, and conference proceedings databases from 2003 till December 2012. In total, 30 publications written in English covering the relevant patient population and topics of interest.ResultsEuropean prevalence ranges from 6% to 34% in diabetes mellitus patients. PDPN has a significant humanistic and economic impact. Patients are limited in their general functioning and their ability to sleep and often experience anxiety and depression. Not surprisingly, PDPN is associated with reduced Health-Related-Quality-of-Life (HRQoL). PDPN patients incur high health care costs due to hospitalizations and outpatient visits. In addition, the painful symptoms cause impaired work productivity. Studies suggest both humanistic and economic burden increase with higher pain severity.ConclusionsThe burden from PDPN appears to be higher with increasing pain severity. More severe pain leads to a higher impairment in daily functioning, sleep and HRQoL. Higher pain intensity also leads to increasing healthcare costs and work productivity losses.Copyright © 2015 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.

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