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Anesthesia and analgesia · Sep 1995
Randomized Controlled Trial Comparative Study Clinical TrialComparison of ondansetron and droperidol in the prevention of nausea and vomiting after inpatient minor gynecologic surgery.
- S Grond, J Lynch, C Diefenbach, K Altrock, and K A Lehmann.
- Department of Anesthesiology and Operative Intensive Care, University of Cologne, Germany.
- Anesth. Analg. 1995 Sep 1;81(3):603-7.
AbstractOndansetron and droperidol are both effective in the prevention of postoperative nausea and vomiting (PONV). In this randomized, double-blind study, 80 inpatients scheduled for minor gynecologic surgery received either ondansetron 8 mg intravenously (i.v.) or droperidol 2.5 mg i.v. 5 min prior to induction of isoflurane-narcotic anesthesia. PONV was absent in 68% of the patients after ondansetron and in 88% after droperidol (P < 0.05). The respective times of complete arousal from anesthesia were 171 min and 229 min (P < 0.001). After ondansetron and droperidol, the incidence of severe drowsiness, restlessness, anxiety, or dizziness was 5% and 28%, respectively (P < 0.01). Thus after minor gynecologic surgery, droperidol 2.5 mg i.v. was superior to ondansetron 8 mg i.v. in the prevention of PONV. However, relative to ondansetron, droperidol entailed an average 1-h delay in recovery from anesthesia.
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