• Respir Physiol Neurobiol · Aug 2002

    Conventional mechanical ventilation of healthy lungs induced pro-inflammatory cytokine gene transcription.

    • Fabienne Brégeon, Antoine Roch, Stéphane Delpierre, Eric Ghigo, Amapola Autillo-Touati, Osamu Kajikawa, Thomas R Martin, Jérôme Pugin, Henry Portugal, Jean-Pierre Auffray, and Yves Jammes.
    • Laboratoire de Physiopathologie Respiratoire (EA 2201), Institut Jean Roche, Faculté de Médecine, Université de la Mediterranée, Bd P Dramard, 13916 Marseille cedex 20, France.
    • Respir Physiol Neurobiol. 2002 Aug 30;132(2):191-203.

    AbstractWe investigated the potential inflammatory reaction induced by mechanical ventilation (MV) using 10 ml/kg tidal volume and no positive end-expiratory pressure (PEEP) in control (C, n = 8), spontaneously breathing (SB, n = 12) and mechanically ventilated (MV, n = 12) rabbits with normal lungs. After 6 h (MV and SB groups) or immediately (C group), lungs were removed for measurement of wet-to-dry (W/D) weight ratio and for bronchoalveolar lavage (BAL). Pulmonary mechanics were also studied. MV animals developed a modest but significant (P < 0.01) impairment of arterial blood oxygenation and had higher W/D lung weight ratio than C ones. In MV group, BAL macrophage count was greater (P < 0.05) than in SB one. MV induced an upregulation of MCP-1, TNF-alpha, and IL-1beta gene transcription (mRNAs), without significant elevation of the corresponding protein cytokines in the BAL supernatant, except for MCP-1 (P < 0.05). These data suggest that MV, even using moderate tidal volume, elicits a pro-inflammatory stimulus to the lungs.

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