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Expert Rev Clin Pharmacol · Nov 2010
Potential clinical application of KGF-2 (FGF-10) for acute lung injury/acute respiratory distress syndrome.
- Xiaocong Fang, Chunxue Bai, and Xiangdong Wang.
- Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China. xiangdong.wang@telia.com.
- Expert Rev Clin Pharmacol. 2010 Nov 1; 3 (6): 797-805.
AbstractAcute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is an acute life-threatening form of hypoxemic respiratory failure with a high mortality rate, and there is still a great need for more effective therapies for such a severe and lethal disease. Dysfunction of endothelial and epithelial barriers is one of the most important mechanisms in hypoxia-associated ALI/ARDS. The acceleration of the epithelial repair process in the injured lung may provide an effective therapeutic target. KGF-2, a potent alveolar epithelial cell mitogen, plays an important role in organ morphogenesis and epithelial differentiation, and modulates a variety of mechanisms recognized to be important in alveolar repair and resolution in ALI/ARDS. Preclinical and clinical studies have suggested that KGF-2 may be the candidate of novel therapies for alveolar epithelial damage during ALI/ARDS.
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