• Clinics in perinatology · Dec 2010

    Review

    Antiretroviral pharmacology: special issues regarding pregnant women and neonates.

    • Mark Mirochnick, Brookie M Best, and Diana F Clarke.
    • Division of Neonatology, Department of Pediatrics, Boston University School of Medicine, 771 Albany Street - Dowling 4111, Boston, MA 02118, USA. markm@bu.edu
    • Clin Perinatol. 2010 Dec 1;37(4):907-27, xi.

    AbstractAntiretrovirals may be used in pregnant women infected with the HIV and their newborns both for treatment of maternal HIV disease and for prevention of mother-to-child transmission of HIV. More than 25 antiretroviral agents in 5 classes have been approved, with new drugs and classes in development. This article reviews current knowledge of the pharmacology of these drugs during pregnancy and in the newborn period, highlighting those pharmacologic issues critical to the safe and effective use of antiretrovirals in these populations.Copyright © 2010 Elsevier Inc. All rights reserved.

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