• John Widger, Mark R Oliver, Michele O'Connell, Fergus J Cameron, Sarath Ranganathan, and Phil J Robinson.
• Department of Respiratory Medicine, The Royal Children's Hospital, Melbourne, Victoria, Australia. jwidger1@yahoo.com
• Plos One. 2012 Jan 1;7(9):e44844.

BackgroundPatients with Cystic Fibrosis (CF) are relatively insulinopenic and are at risk of diabetes, especially during times of stress. There is a paucity of data in the literature describing glucose tolerance during CF pulmonary exacerbations. We hypothesised that glucose tolerance would be worse during pulmonary exacerbations in children with CF than during clinical stability.MethodsPatients with CF, 10 years or older, admitted with a pulmonary exacerbation underwent an OGTT within 48 hours of admission. A repeat OGTT was performed 4 to 6 weeks post discharge when the patients were well.ResultsNine patients completed the study. Four patients were found to have normal glucose tolerance, 3 with impaired and 2 with CF related diabetes during the exacerbation. Mean change in 2-hour glucose was 1.1 mmol (SD = 0.77). At the follow up OGTT, 8 of 9 (89%) remained within their respective glucose tolerance status groupings.ConclusionThe findings of this study show that there is little difference in glucose tolerance during CF exacerbations compared to clinical stability in the majority of patients.

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