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- Sophie Kauffmann, Russell Chabanne, Aurélien Coste, François Longeras, Thomas Sinegre, Jeannot Schmidt, Charles-Marc Samama, Jean-Michel Constantin, and Aurélien Lebreton.
- From the Departments of *Anesthesiology and Intensive Care, †Neurosurgery, and ‡Hematology, and §Emergency Unit, University Hospital of Clermont-Ferrand, Clermont-Ferrand, France; and ‖Department of Anesthesiology and Intensive Care, Cochin University Hospital, Paris, France.
- A A Case Rep. 2015 Jun 1;4(11):151-4.
AbstractThe management of life-threatening bleeding associated with rivaroxaban remains a challenge for physicians due to the lack of evidence about clinically effective options for anticoagulation reversal. We report a favorable outcome in a patient receiving rivaroxaban prophylaxis, who developed a spontaneous subdural hematoma treated by a surgical evacuation and administration of 4-factor prothrombin complex concentrate. Classical coagulation variables were associated with impaired thrombin generation. Reversal with prothrombin complex concentrates improved all thrombin generation measures. Thrombin generation tests may be suitable for assessing the clinical utility of reversal drugs on rivaroxaban-induced coagulopathy.
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