• Pediatr Crit Care Me · May 2005

    Pediatric sepsis definitions: past, present, and future.

    • Richard J Brilli and Brahm Goldstein.
    • Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
    • Pediatr Crit Care Me. 2005 May 1;6(3 Suppl):S6-8.

    ObjectiveTo review the past, present, and future definitions of sepsis and the systemic inflammatory response syndrome in children.MethodsReview of the literature.ResultsThe history and development of the adult-derived sepsis syndrome and its application to pediatric-specific sepsis definitions is provided. Initially, only adult definitions were applied to pediatric studies. Recently, pediatric-specific definitions have been published. The pediatric consensus conference-derived definitions for systemic inflammatory response syndrome, sepsis, severe sepsis, and septic shock are summarized, and their limitations are discussed.ConclusionsThe potential value and inconsistencies of the current pediatric-specific sepsis definitions are discussed. Future direction of the definitions and their applications are presented.

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