• Chong-Rong Lu, Yan-Jie Hu, En-Guo Chen, Yuan-Hua Qiu, and Ke-Jing Ying.
• Department of Respiratory Medicine, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou 310016, China.
• Zhonghua Jie He He Hu Xi Za Zhi. 2010 Feb 1;33(2):104-8.

Objectiveto study the characteristics of volatile organic compounds (VOCs) in exhaled breath of lung cancer patients, and therefore to explore its use in the diagnosis of the disease.Methodsfrom February 2007 to September 2009, 55 patients with lung cancer, 21 patients with benign lung diseases and 30 healthy controls were enrolled in our study. The VOCs in exhaled breath were detected by the SPME (solid phase microextraction)-GC (gas chromatography) system.Resultsheptanal was detected in 45 patients of the lung cancer group, 1 of the benign lung disease group, and 1 of the healthy control group. The positive rate was higher in the lung cancer group as compared to the benign lung disease group and the healthy group combined (P < 0.05). The detection of heptanal was not related to age, smoking, histological type and staging (P > 0.05).Conclusionheptanal maybe a useful marker in VOCs from patients with lung cancer.

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