• Middle East J Anaesthesiol · Feb 1998

    Randomized Controlled Trial Clinical Trial

    Prevention of post-operative nausea and vomiting following laparoscopic surgery--ephedrine vs propofol.

    • K Naguib, H A Osman, H C Al-Khayat, and A M Zikri.
    • Department of Anaesthesia and I.C.U.-Farwania Hospital, Kuwait.
    • Middle East J Anaesthesiol. 1998 Feb 1;14(4):219-30.

    AbstractPostoperative nausea and vomiting (PONV) are relatively common troublesome distressing symptoms. The incidence is reported to be as high as 20-51%. Ninety adult ASA I and II patients scheduled for laparoscopic gynecological or surgical interventions, were randomly and equally assigned to one of the three groups in the immediate postoperative period: Group 1 received 0.1 ml.kg(-1) normal saline intravenously, while Group 2 received 0.5 mg.kg(-1) ephedrine intramuscularly and Group 3 received 0.25 mg.kg(-1) propofol intravenously as preventive antiemetic therapy. Sixty-six, 33 and 50 percent of patients experienced nausea and vomiting syndrome in Group 1, 2 and 3 respectively. Both ephedrine and propofol proved to have antiemetic properties. Ephedrine treated group of patient had significant less emetic score than propofol. No significant hemodynamic changes were recorded in both groups.

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