• A & A case reports · Jan 2015

    Case Reports

    Transient and reproducible loss of motor-evoked potential signals after intravenous levetiracetam in a child undergoing craniotomy for resection of astrocytoma.

    • Allan F Simpao, Luke S Janik, Grace Hsu, Alan Jay Schwartz, Gregory G Heuer, Andrew P Warrington, and Mohamed A Rehman.
    • From the *Department of Anesthesiology and Critical Care, Perelman School of Medicine at the University of Pennsylvania, Philadelphia; †Department of Anesthesiology and Critical Care, The Children's Hospital of Philadelphia, Pennsylvania; ‡Department of Neurosurgery, Perelman School of Medicine at the University of Pennsylvania; §Division of Neurosurgery, Children's Hospital of Philadelphia, Pennsylvania; and ‖Medtronic International, Tolochenaz, Switzerland.
    • A A Case Rep. 2015 Jan 15;4(2):26-8.

    AbstractTranscranial electrical motor-evoked potential (tceMEP) monitoring is used in complex intracranial and spinal surgeries to detect and prevent neurological injury. We present a case of transient, reproducible loss of tceMEPs after an infusion of levetiracetam during craniotomy and tumor resection in a child. Cessation of the infusion resulted in restoration of baseline tceMEPs. When the infusion was resumed at the end of the procedure, a similar decrease in tceMEPs was seen as before, after the infusion was stopped. The surgery and postoperative course proceeded without incident, and the patient experienced a full recovery.

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