• A & A case reports · Jun 2015

    Case Reports

    Lack of Effect of Platelet Transfusions and Desmopressin on Intracranial Bleeding in a Patient Receiving Ticagrelor.

    • Julien Maillard, Vanessa Cartier Faessler, Pierre Fontana, and Fanny Bonhomme.
    • From the *Division of Anaesthesiology, University Hospitals of Geneva, Geneva, Switzerland; and †Division of Angiology and Haemostasis, Geneva University Hospitals, Geneva Platelet Group, Faculty of Medicine, Geneva, Switzerland.
    • A A Case Rep. 2015 Jun 15;4(12):169-71.

    AbstractWe describe a case of a 67-year-old man who required emergency surgery for acute intracranial bleeding after having received a loading dose of aspirin and ticagrelor for an acute ST-elevation myocardial infarction. Before and during the craniocervical decompression, the assessment of platelet function was performed using the Multiplate® analyzer. Biological evaluation of platelet function was consistent with the clinical impression, suggesting that platelet transfusion and desmopressin administration in the presence of ticagrelor had very little, if any, hemostatic effect.

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