Point-of-care testing and molecular diagnostics:

Clin. Lab. Med. · Sep 2009

Point-of-care testing and molecular diagnostics: miniaturization required.

Turnaround time for molecular diagnostic tests is critical in detecting infectious agents, in determining a patient's ability to metabolize a drug or drug class, and in detecting minimal residual disease. These applications would benefit from the development of a point-of-care device for nucleic acid extraction, amplification, and detection. ⋯ The creation of such a device requires miniaturization of current technologies and the use of microfluidics, microarrays, and small-diameter capillary tubes to reduce reagent volumes and simplify heat conduction by convection during nucleic acid amplification. This ideal device may be available in 3 to 5 years and will revolutionize and expand the global availability of molecular diagnostic assays.

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- Frederick L Kiechle and Carol A Holland.
- Department of Pathology, Pathology Consultants of South Broward, LLP, Memorial Regional Hospital, Hollywood, FL 33021, USA. fkiechle@mhs.net
- Clin. Lab. Med. 2009 Sep 1;29(3):555-60.
AbstractTurnaround time for molecular diagnostic tests is critical in detecting infectious agents, in determining a patient's ability to metabolize a drug or drug class, and in detecting minimal residual disease. These applications would benefit from the development of a point-of-care device for nucleic acid extraction, amplification, and detection. The ideal device would have a low cost per test, use a disposable unit use device for all steps in the assay, be portable, and provide a result that requires no interpretation. The creation of such a device requires miniaturization of current technologies and the use of microfluidics, microarrays, and small-diameter capillary tubes to reduce reagent volumes and simplify heat conduction by convection during nucleic acid amplification. This ideal device may be available in 3 to 5 years and will revolutionize and expand the global availability of molecular diagnostic assays.

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Point-of-care testing and molecular diagnostics: miniaturization required.

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