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Randomized Controlled Trial Clinical Trial
Optimal dose of lignocaine for preventing pain on injection of propofol.
- G Gehan, P Karoubi, F Quinet, A Leroy, C Rathat, and J L Pourriat.
- Département d'Anesthésie-Réanimation, CHU Avicenne-Jean Verdier, Université Paris XIII, Bobigny, France.
- Br J Anaesth. 1991 Mar 1;66(3):324-6.
AbstractThe purpose of this study was to define the optimum dose of lignocaine required to reduce pain on injection of propofol. We conducted a prospective, randomized, double-blind trial on 310 patients undergoing anaesthesia. Patients were allocated to four groups according to the lignocaine dosage: group A (control), no lignocaine; group B, lignocaine 0.1 mg kg-1; group C, lignocaine 0.2 mg kg-1; group D, lignocaine 0.4 mg kg-1. Our results showed that a dose of lignocaine 0.1 mg kg-1 significantly reduced the incidence of pain and that there was no improvement when the dose was increased.
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