• Anasthesiol Intensivmed Notfallmed Schmerzther · Jan 2008

    Review

    [Optimization of hepatosplanchnic oxygenation in septic shock].

    • Christopher Beck, Benedikt H J Pannen, and Olaf Picker.
    • Klinik für Anästhesiologie des Universitätsklinikums Düsseldorf. christopher.beck@med.uni-duesseldorf.de
    • Anasthesiol Intensivmed Notfallmed Schmerzther. 2008 Jan 1;43(1):66-70; quiz 71.

    AbstractMicrocirculatory dysfunction, reduced oxygen supply and thus impaired hepatosplanchnic organ function, play a pivotal role in the clinical manifestation of sepsis and septic shock. Early correction of the perfusion mismatch is essential to maintain end-organ and gut mu-cosa barrier function and thus to prevent bacterial translocation, bacteraemia and possible multiple organ failure. This review will outline the clinical tightrope-walk optimizing hepa-tosplanchnic oxygen supply while maintaining adequate end-organ perfusion pressure and highlight the diagnostic challenges and limitations faced in clinical practice.

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